| 摘要 |
<p>PURPOSE:To provide a new benzoic acid ester derivative useful as a synthetic intermediate for agricultural chemicals, pharmaceuticals, etc. CONSTITUTION:The benzoic acid ester derivative of formula I (R1 is H or OH-protecting group; R2 to R4 are lower alkyl), e.g. 3-benzyloxy-2- methoxycarbonylacetophenone dimethyl acetal. The compound of formula I can be produced in high yield by reacting an acetal derivative of formula II successively with an alkyllithium and a haloformic acid ester of formula XCOOR2 (X is halogen; R2 is lower alkyl) in the presence of an aliphatic or aromatic hydrocarbon solvent.</p> |
