发明名称 |
SUSTAINED AND CONTROLLED RELEASE OF WATER INSOLUBLE POLYPEPTIDES |
摘要 |
There is disclosed a pharaceutical composition for sustained and controlled release of drug over an extended period of time comprising a polylactide, a copolymer of lactic and glycolic acid, a mixture of such polymers and a water-insoluble peptide which, when placed in an aqueous physiologically-type environment releases the peptide in continuous manner for a period of at least one week, and with an initial release for the first twenty-four hours of not more than 30% of the total amount released. There is thus provided the control of the release pattern and in general a decrease of the initial burst effect.
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申请公布号 |
US5192741(A) |
申请公布日期 |
1993.03.09 |
申请号 |
US19880247060 |
申请日期 |
1988.09.20 |
申请人 |
DEBIOPHARM S.A. |
发明人 |
ORSOLINI, PIERO;MAUVERNAY, ROLLAND-YVES;DEGHENGHI, ROMANO |
分类号 |
A61K9/14;A61K9/00;A61K9/16;A61K9/22;A61K9/26;A61K9/52;A61K38/00;A61K38/04;A61K38/09;A61K38/11;A61K38/21;A61K38/22;A61K38/23;A61K38/26;A61K38/28;A61K38/55;A61K47/00;A61K47/34 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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