发明名称 Process for the synthesis of glucuronides of 4,5-epoxymorphinans
摘要 A method for synthesizing glucuronides of 4,5-epoxy morphinanes having formula (I). The method comprises, optionally after acetylation, a first step of reacting a compound of formula (I') with a derivative of formula (II), and a second step of hydrolyzing the resulting compound. The method is characterized in that the hydrolysis step is performed by means of at least one alkali metal, preferably lithium, which is provided in the form of a metal or of at least one salt.
申请公布号 FR2680786(A1) 申请公布日期 1993.03.05
申请号 FR19910010927 申请日期 1991.09.04
申请人 IREPA 发明人 MERTZ ALFRED, ADOLPHE, HENRI;ADOLPHE;HENRI
分类号 C07H17/00;(IPC1-7):C07D489/00 主分类号 C07H17/00
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