PROTEINS USEFUL IN THE REGULATION OF kappa B-CONTAINING GENES, CORRESPONDING DNA AND RNA SEQUENCES

摘要

Proteins, and corresponding DNA and RNA sequences, useful for the regulation of expression of kappa B-containing genes are disclosed. These proteins are useful to either stimulate or inhibit the expression of kappa B-containing genes. Proteins stimulating the expression of kappa B-containing genes have an amino acid sequence at least 80 % identical to the amino acid sequence of from position 1 to position 374 of p100 [SEQ ID NO: 2]. Proteins having an inhibitory effect on the expression of kappa B-containing genes have sequences either at least 80 % identical to the amino acid sequence of from position 407 to the carboxyl end of p100 [SEQ ID NO: 2] or having an amino acid sequence at least 80 % identical to the amino sequence of either from position 1 to 100 or from position 101 to position 374 of p100 [SEQ ID NO: 2].