| 摘要 |
The present invention discloses a novel, highly potent decapeptide of the formula: NH2-Ser-Phe-Pro-Thr-Thr-Lys-Thr-Tyr-Phe-Pro-COOH, or a synthetic analogue or pharmaceutically acceptable salt thereof, which compound inhibits the release of prolactin and luteinizing hormone by effecting increased turnover and release of the potent catecholamine and prolactin inhibiting factor dopamine, thereby regulating the release of gonadotropins and prolactin by the pituitary gland in mammals. The invention is also directed to various methods of use of the novel compound and to pharmaceutical compositions therefor. |
