| 摘要 |
<p>A delayed onset transdermal drug delivery device (11) exhibiting a delay period of at least eight hours comprising a laminated composite of (A) a top backing layer (12); (B) a pressure rupturable layer (13) underlying (B); (C) a reservoir of a solution of drug (14) in a liquid vehicle between (A) and (B) underlying layer (13) is a hard, solid body (15) to which finger pressure may be applied to facilitate the rupture of layer (13); (D) a wick layer (16) underlying (B) for dispersing the drug once (B) is ruptured; (E) a first adhesive layer (17) underlying (D) that is permeable to the drug; (F) a first polymer membrane (18) that is permeable to drug but substantially impermeable to the adhesive of (E); (G) a microporous membrane (19) underlying (F) which is itself impermeable to the drug and whose pores are unfilled; (H) a second polymer membrane (20) that underlies the microporous membrane (19) that is permeable to drug but substantially impermeable to the adhesive of (I) below; and (I) a second adhesive layer (21) underlying (H) that is permeable to the drug.</p> |
