发明名称 |
Production of fluoxetine and new intermediates. |
摘要 |
<p>4-methyl-3-[(4-trifluormethyl)phenoxy]-3-phenyl propylamine (I) is prepared by reacting 3-dimethylamino-1-phenyl-1-propanol (III) with haloformate (VII) to obtain a substituted propyl carbamate (IX) which is hydrolyzed under basic conditions to yield methylamino-1-phenyl-1-propanol (X). The methylamino-1-phenyl-1-propanol is then converted to fluoxetine (I) by reaction with 4-halobenzotrifluoride (XI). In the process certain substituted carbamates are obtained as intermediates.</p> |
申请公布号 |
EP0529842(A2) |
申请公布日期 |
1993.03.03 |
申请号 |
EP19920307190 |
申请日期 |
1992.08.06 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
SCHWARTZ, EDUARD;KASPI, JOSEPH;ITOV, ZINOVI;PILARSKI, GIDON |
分类号 |
C07C213/06;C07C217/48;C07C271/16;A61K31/135;A61P25/24;A61P25/26 |
主分类号 |
C07C213/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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