| 摘要 |
PCT No. PCT/GB92/01389 Sec. 371 Date Feb. 28, 1994 Sec. 102(e) Date Feb. 28, 1994 PCT Filed Jul. 27, 1992 PCT Pub. No. WO93/03152 PCT Pub. Date Feb. 18, 1993Insulin-like Growth Factor II (IGF-II) analogues in which at least one of R37 and R38 is replaced with another amino add residue, the most preferred being IGF-II R37Q R38Q, can readily be produced in E. coli, unlike natural IGF-II, which is cleaved on secretion. The analogues retain activity on the type I and type II IGF receptors but have lower affinity for the insulin receptor; they are therefore more specific in their action. |
