摘要 |
According to this process, one effects a stereospecific reduction of the two hydroxyl groups of an ether-diol by a mixture (titanium trichloride, lithium aluminum hydride) at a temperature between 5 DEG C. and about 40 DEG C. and that optionally, one converts the resulting ether into vitamin A, retinol or retinoic acid. Application to the synthesis of all-trans compounds selected from the group consisting of vitamin A and its ethers, retinol and retinoic acid, and their 13-cis isomers.
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