| 摘要 |
NEW MATERIAL:The compound of formula I [R<1>, R<2> and R<8> are H, CH, halogen, (halo)alkyl, alkoxy, alkylthio, alkylsulfinyl, etc.; R<3> is alkyl or mono- or di-alkylamino; R<4> is acyl, CN, carboxy, mercapto, (substituted) unsaturated 5-membered heterocyclic group, group of formula II, formula III (R<6> is H, amino or alkyl; R<7> is OH, alkoxy, ureido, etc.), etc.; R<5> is H, halogen, alkyl or alkanoyl] and its salt. EXAMPLE:4'-Acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide. USE:An anti-inflammatory agent and analgesic agent. PREPARATION:The compound of formula I can be produced e.g. by reacting a compound of formula IV with a sulfonylation agent of formula V preferably in the presence of a base. |
