New psychotherapeutic pyrrolo-2,3-c pyridine deriv. - useful as benzodiazepine antagonists, inverse agonists and agonists

摘要

Pyrrolo(2,3-c)pyridine derivs. of formula (I) and their isomers and acid addn. salts. are new: R2 = H or a protecting gp., R3 = halo, CHRCH2X, CH=CHX, a gp. of formula (a), 6-12C aryl (opt. substd. by halo, NH2, (A)2N, A, AO or phenoxy), COR, or heteroaryl (opt. substd. by halo, A or AO); A = 1-4C alkyl; R = H or A; X = H. A, AOCH2, 3-7C cycloalkyl, or phenyl (opt. substd. by halo, NH2, A or AO); R4 = H, A or AO-(1-2C)alkyl; R5 = COOR2 or a gp. of formula (i): R2 = A; R6 = H, A or 3-7C cycloalkyl. USE/ADVANTAGE - (I) are benzodiazepine receptor agonists, antagonists and inverse agonists and useful as psychopharmaceuticals. Admin. is enteral or parenteral in doses of 0.1-1000 (esp. 1-30) mg/day.