| 摘要 |
PURPOSE:To obtain the titled compound useful as a synthetic intermediate for vitamin E, easily, in high yield and selectivity, by carrying out the catalytic oxidation of 2,3,6-trimethylphenol with O2 in a specific solvent in the presence of a Cu halide complex as a catalyst. CONSTITUTION:A Cu halide complex of formula [M is alkali metal of the group IA of the periodic table or ammonium; Cu(II) is bivalent copper; X is halogen; lis 1-3; m and p are 1 or 2; n is 3-8; l+2mp=np] such as Li[CuCl3].2H2O, etc. and an alkali metal halide such as LiCl are dissolved in water, and the obtained catalyst layer is adjusted to 2--0.5 pH. 2,3,6-Trimethylphenol is charged to the reactor in the presence of water and a 4-10C aliphatic alcohol, and subjected to the catalytic oxidation with O2 to obtain the objective compound. EFFECT:There occurs no deactivation of the catalyst with water. The rate of reaction is high, and the size of the reactor can be substantially reduced. The catalyst can be recycled and reused, and the product can be separated effectively. |
