| 摘要 |
A method for diagnostic use in an MRI agent is disclosed wherein the composition comprises a complex of a macrocyclic aminophosphonic acid, preferably 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid, and a paramagnetic nuclide, such as Gd<+><3>, Mn+<2>, Mn<+><3> or Fe<+><3>. The composition is bone seeking and stable over a wide pH range. |
