摘要 |
<CHEM> Compounds of formula (I) or salts thereof, wherein the dotted line represents a single or double bond, R<1> is alkyl or amino optionally substituted by alkyl, alkanoyl or benzyl group; R<2>, R<3>, R<4> and R<5> are the same or different and each is selected from hydrogen, phenyl, halo, nitro, a group S(O)nR<8> wherein n is the integer 0, 1 or 2 and R<8> is halo or alkyl or a group NR<9>R<10> wherein R<9> and R<10> are both hydrogen, a group NR<11>R<12> wherein R<11> and R<12> are the same or different and each is hydrogen or alkyl, a group OR<13> wherein R<13> is hydrogen or C1-4 alkyl optionally substituted by halo; a C1-4 aliphatic group optionally substituted by a group OR<14> or NR<14>R<15> wherein R<14> and R<15> are the same or different and each is hydrogen or alkyl; or two of R<2> to R<5> are linked together to form a benzo group, or one of R<2> to R<5> is a group -X-Y-R<16> wherein X is CH2, NR<17>, CO or S(O)m, and Y is CH2, NR<17>, O, or S(O)m, or -X-Y- is a group -O-, -NR<17>-, -CH=CH- or -N=N-, are disclosed as pharmacological agents useful in the treatment of tumours. Pharmaceutical compositions and methods for the preparation of compounds of formula (I) are also described. |