17-SUBSTITUTED ANDROSTA-1,4-DIEN-3-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention relates to new 17-hydroxy androsta-1,4-diene-3-one derivatives of the following formula wherein each of R and R3, independently, is hydrogen or C1-C6 alkyl; R1 is hydrogen, halogen or C1-C6 alkyl; R2 is hydrogen or C1-C6 alkyl; R4 is hydrogen or fluorine; R5 is a) hydrogen or C1-C6 alkyl; b) phenyl unsubstituted or substituted by one or two substituents independently chosen from C1-C6 alkyl, halogen and amino; c) an acyl group; or d) a hydroxy protecting group; and the pharmaceutically acceptable salts thereof, which are useful in therapy, in particular as anti-cancer agents.