The present invention comprises a novel culture process in which cells or subcellular biocatalysts are confined within a chamber which is capable of being pressurized. The cells are immersed in a nutrient medium with no gas phase in contact with the medium. Cells or subcellular biocatalysts which are cultured according to the present invention show significantly increased yields of cellular products when compared to conventional culturing techniques.
申请公布号
WO9303135(A1)
申请公布日期
1993.02.18
申请号
WO1992US06640
申请日期
1992.08.07
申请人
BIOTEC RESEARCH & DEVELOPMENT, INC.
发明人
HERMAN, HEATH, H.;HERMAN, KENT, M.;PITT, EDWARD, J.