发明名称 |
IMPROVED EXPRESSION OF INFLUENZA A M2 PROTEIN IN BACULOVIRUS AND USES OF M2 PROTEIN |
摘要 |
2111116 9303173 PCTABS00019 The present invention relates to baculovirus-expressed influenza antigens, in particular, to the influenza A membrane protein, M2, expressed from Autographa Californica nuclear polyhedrosis virus (AcNPV). The present invention further relates to a method to increase the yield of baculovirus-expressed M2 proteins in host cells by culturing the recombinant baculovirus infected host cells with an amantadine-like drug. Other aspects of the present invention relate to the use of baculovirus-expressed M2 proteins in reproducible and routine assays for the seradiagnosis of influenza A virus infections as an alternative to the more burdensome complement fixation and hemagglutination tests.
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申请公布号 |
CA2111116(A1) |
申请公布日期 |
1993.02.18 |
申请号 |
CA19922111116 |
申请日期 |
1992.07.29 |
申请人 |
UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (THE) |
发明人 |
KENDAL, ALAN P.;BLACK, RENEE;ROTA, PAUL A. |
分类号 |
C07K14/195;C07K14/005;C07K14/11;C07K14/705;C12N5/10;C12N7/00;C12N15/09;C12P21/00;C12R1/91;G01N33/569;(IPC1-7):C12N15/44;C12N5/02 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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