| 发明名称 |
PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS |
| 摘要 |
2114934 9302703 PCTABS00019 Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents, e.g., as antitumor agents.
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| 申请公布号 |
CA2114934(A1) |
申请公布日期 |
1993.02.18 |
| 申请号 |
CA19922114934 |
申请日期 |
1992.08.04 |
| 申请人 |
|
发明人 |
MARTIN, MARK T.;SMITH, RODGER G.;TITMAS, RICHARD C.;WILLIAMS, RICHARD O.;KAMIREDDY, BALREDDY;MASSEY, RICHARD J.;NAPPER, ANDREW D.;SIMPSON, DAVID M.;VON BORSTEL, REID;CASADEI, JAN M.;KENTEN, JOHN H. |
| 分类号 |
A61K31/195;A61K31/425;A61K31/505;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K39/385;A61K39/395;A61K47/48;A61P31/12;A61P43/00;C07C311/19;C07D227/02;C07D233/64;C07D233/88;C07D405/04;C07D417/12;C07D417/14;C07F9/24;C07F9/26;C07F9/40;C07F9/6509;C07F9/6571;C07F9/6574;C07H15/252;C07H19/04;C07H19/067;C07H19/09;C07H19/10;C07H19/11;C07K16/46;C12N15/09;C12P21/08;C12R1/92;G01N33/50;G01N33/53;(IPC1-7):C07H15/252;C07K2/00;C12Q1/02;C07C235/44;C07K16/44 |
主分类号 |
A61K31/195 |
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