CLONING AND EXPRESSION OF A VARIANT GENE OF PLATELET FACTOR 4 AND COMPOSITIONS THEREOF TO MODULATE IMMUNE RESPONSES

摘要

The present invention provides for the purification from native sources or the cloning and expression of a variant form of platelet factor 4 and also provides recombinant DNA vectors and methods for the expression and recovery of the platelet factor 4 variant. Also provided are compositions and methods for modulating immune responses in mammals comprising immunomodulating effective amounts of platelet factor 4 variant.