Irreversible ligands for nonsteroidal antiinflammatory drug and prostaglandin binding sites

摘要

Compounds such as 1-(4-bromoacetamidobenzyl)-5-methoxy-2-methylindole-3-acetic acid, N-(4-bromoacetamidophenyl) anthranilic acid and N-(3-bromoacetamidophenyl) anthranilic acid function as irreversible ligands for nonsteroidal antiinflammatory drug (NSAID) and prostaglandin binding sites. It is therefore expected that these compounds, and analogs thereof, will have utility as antiinflammatory drugs, as affinity labeling agents and as ligands for use in affinity chromatography.