发明名称 |
PROCESS FOR PREPARING OF TRANS-1/4-(2-DIMETHYLAMINOETHOXY)PHENYL/-1,2-DIPHENYL-1-BUTENE HYDROCHLORIDE |
摘要 |
The compound, prepared by this method, is familiar as tamoxifen hydrochloride and is applicable in medicine. The method is easily implemented in industrial conditions for preparation of a product of high purity and yield. Following the method,1-/4-(2-dimethylaminoethoxy)phenyl/-1,2-diphenyl-1-butene is heated in a medium of hydrochloric acid at a temperature between 50 and 55 degrees C for 5 to 9 hours. The raw product is separated from the reaction mixture after adding water and filtration, followed by recrystallisation from methylisobutylketone and without preliminary drying.
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申请公布号 |
BG51092(A1) |
申请公布日期 |
1993.02.15 |
申请号 |
BG19900091748 |
申请日期 |
1990.04.12 |
申请人 |
DRUZHESTVEN NAUCHNO-IZSLEDOVATELSKI KHIMIKO-FARMATSEVTICHEN INSTITUT |
发明人 |
KONSTANTINOVA, RUMJANA G.;ELENSKA-ZHELJAZKOVA, MAJA I.;DIMANOVA, RADOST G.;KAZAKOV, ATANAS G.;HEMEP, PX;NIKOLOVA-NINOVA, EVDOKIJA A.;GEORGIEV, ALEKSANDAR KH.;KATSOV, GEORGI I. |
分类号 |
C07C215/60;(IPC1-7):C07C215/60 |
主分类号 |
C07C215/60 |
代理机构 |
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地址 |
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