| 摘要 |
1,2-Dihydro-8-piperazinyl-4-phenylimadazo pyridopyrazine oxides and 1,2-dihydro-8-piperazinyl-4-phenylimidazo quinoxaline oxides of general formula (I) are useful in the treatment of cancer, in particular hypoxic tumours:- <IMAGE> where R<1> is alkyl of 1 to 6 carbon atoms, benzyl, phenyl, R<4>SO<2>-where R<4> is C1-6 alkyl, NH2COCH2-, R<5>-CO-where R<5> is alkyl of 1 to 6 carbon atoms, aminomethyl, pyridinyl, phenyl, halophenyl or <IMAGE> -where R<6> is alkyl of 1 to 6 carbon atoms; R<2> is phenyl unsubstituted or substituted by 1 or 2 substituents selected from halogen and alkoxy of 1 to 6 carbon atoms; R<3> is hydrogen or halogen; and X is-CH=or-N=;or a pharmaceutically acceptable salt thereof.d 1,2 |
