摘要 |
<p>Described is a process for producing a new immunosuppressant, a C-31 desmethyl, C-19/C-22 cyclic hemiketal biotransformation analog (Compound I) of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces, lavendulae ATCC No. 55209. Also disclosed is the C-31 methylated devivative (Compound II) of Compound I produced by enzymatic methylation using 31-O-desmethylimmunomycin O-methyl transferase, (DIMT), a methyl transferase enzyme. The macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants. <IMAGE></p> |
申请人 |
MERCK & CO. INC. |
发明人 |
CHEN, SHIEH-SHUNG TOM;WHITE, RAYMOND F.;DEZENY, GEORGETTE;ARISON, BYRON H.;BEATTIE, THOMAS R.;HALE, AMY M.;DUMONT, FRANCIS |