Thiadiazines and pharmaceutical compositions thereof as well as method of use

摘要

New heterocyclic compounds of formula I <IMAGE> I In which Het means one of following groups; <IMAGE> wherein R11, R13 and R14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, -CH=CH-, or -CH2-CH2-group; R1 and R2 independently mean nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; <IMAGE> wherein R6 means hydrogen or lower alkyl group, R8 means lower alkyl, R7 means cyano or COOR10, wherein R10 means hydrgen or lower alkyl or R1 and R2 together form a susbtituted or unsubstituted 5 or 6 membered ring which may contain 1 to 2 heteroatom N; R3, R4, and R5 means independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.