OPTICAL RESOLUTION OF OPTICALLY ACTIVE GLUTARIC ACID ESTER DERIVATIVE

摘要

PURPOSE:To perform optical resolution of a specific racemic mixed solution in high yield and optical purity by reacting the racemic mixed solution with (+)-dehydroabietylamine, thereby forming (+)-dehydroabietylamine salt of R(-)- glutaric acid ester. CONSTITUTION:A racemic mixed solution of a glutaric acid of formula [R<1> is hydroxyl-protecting group; R<2> is (substituted) lower alkyl; * represents asymmetric carbon atom] is treated with (+)-dehydroabietylamine to form (+)- dehydroabietylamine salt of R(+)-glutaric acid ester and effect the optical resolution of optically active glutaric acid ester derivative. The produced salt is subjected to salt-decomposition to recover R(-)-glutaric acid ester and S(+)- glutaric acid ester.