| 摘要 |
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein Y is C1-C6 alkylene optionally substituted by C1-C6 alkyl; R is H, OH, halo, C1-C4 alkyl or C1-C4 alkoxy; R<1>, R<2>, R<3> and R<4> are each independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, OH, halo and CF3; one of R<6>, R<7> and R<8> is a group of formula (a) or (b), and the remainder, together with R<5> and R<9>, are each independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, halo and halo(C1-C4)alkyl; R<10> is COOH, COOR<11> or CONR<12>R<13>; R<11> is a biolabile ester-forming group; R<12> and R<13> are each independently selected from H and C1-C4 alkyl; R<14> is H, C1-C6 alkyl, C3-C7 cycloalkyl or aryl; and ''aryl'', used in the definitions of R<6>, R<7>, R<8> and R<14>, means phenyl optionally substituted by C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, OH, halo, CF3, halo(C1-C6 alkyl), nitro, amino, C2-C6 alkanamido, C2-C6 alkanoyl or phenyl: together with pharmaceutical compositions containing, processes for the preparation of and uses of, such compounds. |
