TRIFUNCTIONAL COMPOUNDS HAVING SPECIFICITY FOR MULTI-DRUG RESISTANT CELLS

摘要

The present invention relates to trifunctional compounds having specific reactivity with P-glycoproteins associated with multi-drug resistant (MDR) tumor cells. The compounds can optionally be specific for diagnostic and/or therapeutic agents as well and are thus contained in pharmaceutical compositions. Methods for detecting and treating patients with tumors expressing P-glycoproteins associated with MDR cells are also provided.