| 摘要 |
Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C1-6-alkyl ether and C1-6-alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A2 inhibitors that are also useful as antiinflammatory agents. A87689 compounds, including its C1-6-alkyl ether and C1-6-alkanoyl derivatives, used alone or in combination with nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and HIV protease inhibitors, are also useful for managing retroviral infections in mammals and are particularly useful for managing HIV and/or AIDS in humans. |
