BENZODIAZEPINE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY

摘要

Compounds of formula (I), and salts and prodrugs thereof, wherein one of W, X, Y or Z is N, another of W, X, Y or Z is N, O or S atom or NR8, and the other two of W, X, Y and Z are N or CR8, and the dotted circle represents two double bonds; R1 represents optionally substituted C¿1-6? alkyl, or C3-7 cycloalkyl; R?2¿ represents optionally substituted C¿1-6? alkyl, halo, CONR?6R7¿, SO(C¿1-6?alkyl), SO2(C1-4alkyl), CONHSO2R?9, SO¿2NHCOR?9, SONHR10¿, cyano, or B(OH)¿2; R?3 represents H, C¿1-6? alkyl or halo; m is 0, 1 or 2; n is 0, 1, 2 or 3; are CCK and/or gastrin antagonists. They and compositions thereof are therefore useful in therapy.