| 摘要 |
<p>In this method, one attaches one or more chelatant molecules to a mono- or polyamino intermediate compound (I) which is temporarily immobilized on a solide phase by a splittable bond. Thereafter, said bond is split to release the desired conjugate moiety, whereby a reactive site is generated at the splitting site. The conjugate can be coupled to a protein homing factor using said reactive site; the latter being single per chelatant molecule, undesirable cross-linking during conjugation is substantially avoided.</p> |
