发明名称 |
Asymmetric synthesis of taxol side chain. |
摘要 |
<p>The present invention relates to a process for the preparation of (3R, 4S)-3-hydroxy-4-phenyl-2-azetidinone derivatives which are useful intermediates in the synthesis of taxol from baccatin III, and to compounds of formula (III) which are produced in said process: <CHEM> wherein Ar is phenyl; R<1> is hydrogen, an acyl radical of a carboxylic acid, or a carbonic acid ester radical; R<2> is hydrogen or a carboxy protecting group; and R<3> is hydrogen or a hydroxy protecting group.</p> |
申请公布号 |
EP0525589(A1) |
申请公布日期 |
1993.02.03 |
申请号 |
EP19920112442 |
申请日期 |
1992.07.21 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
FARINA, VITTORIO;HAUCK, SHEILA I. |
分类号 |
C07D305/14;A61K31/355;C07B53/00;C07D205/08;C07F7/18 |
主分类号 |
C07D305/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|