发明名称 |
Matrix metalloprotease inhibitors |
摘要 |
Compounds of the formulas <IMAGE> (1) or <IMAGE> (2) wherein R1 is H and R2 is alkyl (3-8C) or wherein R1 and R2 taken together are -(CH2)n- wherein n=3-5; R3 is H or alkyl (1-4C); R4 is a substituted or unsubstituted fused or conjugated bicycloaryl methylene; X is OR5 or NHR5, wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), aryl alkyl (6-16C); or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine are useful for treating conditions which are characterized by unwanted matrix metalloprotease activities.
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申请公布号 |
US5183900(A) |
申请公布日期 |
1993.02.02 |
申请号 |
US19900615798 |
申请日期 |
1990.11.21 |
申请人 |
GALARDY, RICHARD E.;GROBELNY, DAMIAN |
发明人 |
GALARDY, RICHARD E.;GROBELNY, DAMIAN |
分类号 |
A61K31/165;A61K31/405;A61K31/454;C07C259/06;C07D209/20 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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