| 摘要 |
New antibacterial spirocyclic 6-amido carbapenems of the structural formulas: <IMAGE> <IMAGE> wherein R1 is hydrogen, C1-8 substituted or unsubstituted alkyl, or C6-10 substituted or unsubstituted aryl; R5 is hydrogen or a protecting group for alcohol; R6 is hydrogen or a protecting group for amido nitrogen; R7 is hydrogen or a protecting group for amido nitrogen; and R8 is hydroxy, hydrogen, C1-8 substituted or unsubstituted thioalkyl, C6-10 substituted or unsubstituted thioaryl, 5 or 6 membered, substituted or unsubstituted thioheteroaryl; and a process for their synthesis through novel spirocyclic 4-amido azetidinones are disclosed.
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