PRODUCTION OF P-TOLUENESULFONYLACETIC ACID

摘要

PURPOSE:To obtain the subject compound in high yield by preparing an aqueous solution of sodium p-toluenesulfinate as an intermediate from inexpensive p- toluenesulfonyl chloride as a starting raw material and adjusting pH with a base and/or adding an iodide during reaction with chloroacetic acid. CONSTITUTION:For example, sodium sulfite and a base are dissolved or suspended in water and reacted with sodium p-toluenesulfonyl chloride to give an aqueous solution of sodium p-toluenesulfinate as an intermediate raw material. In reacting the aqueous solution with chloroacetic acid, the reaction solution is adjusted to pH1.0-4.0 with a base such as sodium hydroxide and/or an iodide such as lithium iodide or sodium iodide (preferably about 0.02-0.06mol based on 1.0mol sodium p-toluenesulfinate) to give p-toluenesulfonylacetic acid in high yield. p-Toluenesulfonylacetic acid is useful as an intermediate raw material for diiodomethyl-p-tolylsulfone suitable as industrial germicide and fungicide.