ASYMMETRIC SYNTHESIS OF TAXOL SIDE CHAIN

摘要

CT-2152 The present invention relates to a process for the preparation of (3R, 4S)-3-hydroxy-4-phenyl-2-azetidinone derivatives which are useful intermediates in the synthesis of taxol from baccatin III, and to compounds of formula (III) which are produced in said process: wherein Ar is phenyl; R1 is hydrogen, an acyl radical of a carboxylic acid, or a carbonic acid ester radical; R2 is hydrogen or a carboxy protecting group; and R3 is hydrogen or a hydroxy protecting group.