| 摘要 |
178/RJN116 18459 TITLE OF THE INVENTION NEW CATECHOL TYPE NON-STEROIDAL DRUGS AS 5-ALPHA REDUCTASE INHIBITORS Described are new non-steroidal drugs for treatment of benign prostatic hyperplasia and other disorders mediated by high 5-alpha reductase activity, or high dihydrotestosterone levels, and other conditions of hyperandrogenic stimulation, of the formula: wherein A is an 1,2-disubstituted aromatic ring; 178/RJN116 - ii - 18459 wherein X is independently O, S, SO, or SO2; R is H, C1-C4 alkyl, phenyl or substituted phenyl, halo, haloalkyl, hydroxy, carboxy, cyano, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, nitro, amino, C1-C4 mono or di-alkylamino; R' and R" are independently H, halo, C1-C4 alkyl or C1-C4 alkoxy, amino, or oxo, where CH-R' or CH-R" in the formula become -C=O; y is 1-6; z is 6-20; and 66/RJN116 - iii - 18459 wherein and can independently represent substituted or unsubstituted alkyl radicals or alkenyl radicals containing at least one alkene bond; and pharmaceutically acceptable salts and esters thereof.
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