摘要 |
1. A method for purification of piroxicam, with formula 1, from a raw product, mixed with an adsorbent from the non-organic silicon derivative group, obtained from a high-temperature reaction of ester with general formula 2, wherein R denotes a methyl or an ethyl group, with 2-aminopyridine and its maintenance in the required crystal form with optimum biological availability in oral preparations, characterized in that the raw product is eluted from the solid phase with halogenoalkane at a raised temperature and to the eluate thus obtained lower aliphatic alcohol is added, halogenoalkane is removed through distillation, and piroxicam, crystallized from the alcohol, is isolated and recrystallized by a known method from a dipolar aprotic solvent.<IMAGE>
|