HIRUDINANALOGE UND VERFAHREN ZU IHRER HERSTELLUNG

摘要

A compound which is a polypeptide of formula (I) P-(Gly)n-X wherein P is HV1 or HV1(Val 65) polypeptidic moiety having an amino acid sequence as depicted in Figure 1; -(Gly)- is the bivalent radical of glycine, -NH-CH2-CO-; X is -OH or -NH2; and n is zero or 1; with the provisos that when P is HV1 and n is zero, X must be NH2, and that when n is 1, X must be -OH; or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful as antithrombotic or anticoagulation agents.