摘要 |
The invention concerns the use of oxazolo-[2,3-a]isoindole and iminazo[2,1-a]isoindole derivatives as antiviral drugs, as well as optically active derivatives, new oxazolo-[2,3-a]isoindole derivatives, a method for preparing them and drugs containing these compounds. In particular, the subject matter of the invention is the use of oxazolo-[2,3-a]isoindole and imidazo[2,1-a]isoindole derivatives of general formula (I) to produce antiviral drugs. In formula (I), X stands for an oxygen atom or a sulphur atom, the imino group =NH or a =N-C1-C5 alkylimino group, Y stands for an oxygen atom or the group NR<7>, wherein R<7> is a hydrogen atom or a C1-C6 alkyl residue or a C1-C6 acyl residue, R is a hydrogen atom, a straight-chain or branched, saturated or unsaturated aliphataic residue containing 1-9 carbon atoms, possibly substituted by phenyl, or a phenyl ring possibly substituted one or more times, or a carbocyclic or heterocyclic ring, R<1> and R<2> stand for a hydrogen atom, a straight-chain or branched, saturated or unsaturated aliphatic residue with 1 to 6 carbon atoms, R<3>-R<6> stand for hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylmercapto, amino, C1-C6 alkylamino, di-C1-C6 alkylamino, halogen, cyano, hydroxy, carboxy, aminocarbonyl, substituted aminocarbonyl or C1-C6 alkoxycarbonyl. The invention also concerns their tautomers, enantiomers, diastereomers and physiologically acceptable salts.
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申请人 |
BOEHRINGER MANNHEIM GMBH, 6800 MANNHEIM, DE |
发明人 |
KOENIG, BERNHARD, DIPL.-BIO. DR.RER.NAT., 8137 BERG, DE;LESER, ULRIKE, DIPL.-BIOL. DR., 8000 MUENCHEN, DE;MERTENS, ALFRED, DR.RER.NAT., 6905 SCHRIESHEIM, DE;SCHAEFER, WOLFGANG, DR.RER.NAT.;POLL, THOMAS, DIPL.-CHEM. DR., 6800 MANNHEIM, DE |