ANALGESIC USE OF BENZOBICYCLIC CARBOXYAMIDES

摘要

A compound of the formula (I) or a pharmaceutically acceptable salt thereof is used for the manufacture of a medicament for the treatment of algesia. Z represents the carbon and hydrogen atoms necessary to complete a substituted or unsubstituted, saturated or unsaturated, 5- to 7-membered ring. R<1>, R<2>, and R<3> may be the same or different and represent a member selected from hydrogen, lower alkyl, cycloalkyl, lower alkoxy, amino, lower alkyl substituted amino, acylamido, sulfonamido, halogen, and nitro. A represents a moiety selected from formulae (II), (III), (IV), (V), (VI) and (VII) W represents a single boad or the carbon and hydrogen atoms necessary to complete a 3- to 8-membered saturated or unsaturated ring. Y represents a single bond or the carbon and hydrogen atoms necessary to complete a 4 to 8 membered saturated or unsaturated ring R<6> is selected from hydrogen, lower alkyl, phenyl, phenalkyl, fluorine-substituted alkyl, propargyl, and allyl, R<7> and R<8> may be the same or different and are selected from lower alkyl, and lower hydroxyalkyl, M<1> and M<2> are the same or different and represent hydrogen or methyl, R<1><1> and R<1><2> are the same or different and represent lower alkyl, cycloalkyl, or phenalkyl. n is 0 or an integer of 1 to 3. When Z represents the atoms accessary to complete a 2,3,4,5-tetrahydro-1-benzoxepin ring, R<1> may not equal hydrogen, amino, or alkylamino and R<2> may not equal hydrogen or halogen. When Z represents the atoms necessary to complete a 2,2-dimethyl-2,3-dihydrobenzofuran ring, R<1>, R<2> and may not simultaneously equal hydrogen and when R<2> is flourine, R<1> and R<3> may not equal hydrogen. When Z represents the atoms necessary to compLete a 2,2-dimethyl or a 2,2-diethyl 3,4-dihydrobenzopyran ring, R<2> may not equal fluorine or chlorine when R<1> and R3 are hydrogen.