| 摘要 |
The present invention is directed to a new class of piperidinyl benzimidazole antihistamines which can be described by the following formula: <IMAGE> FORMULA I wherein Y is represented by CO or CHOH; m is an integer from 1 to 2; R is represented by C1-4 alkyl, C1-4 alkoxy, halogen, hydroxy and hydrogen; X is represented by hydrogen, COOR2, in which R2 is represented by a C1-4 alkyl, or an alkylene phenyl radical of the formula: <IMAGE> FORMULA II wherein T is represented by CHOH, CO, O, or a direct bond; R1 is represented by C1-4 alkyl, C1-4 alkoxy, halogen, hydroxy, 2,2-dimethyl ethanoic acid and hydrogen; n is an integer from 1 to 5; and the pharmaceutically acceptable acid addition salts thereof.
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