| 摘要 |
PURPOSE:To obtain the subject new compounds useful as medicines such as antiphlogistics, anti-rheumatics, antimicrobial agents or antiviral agents. CONSTITUTION:A compound expressed by formula I [R<1> is pyridyl or (substituted)phenyl; R<2> is pyridyl or NHR<5> (R<5> is H, lower alkyl, formyl, etc.); R<3> is pyridyl; R<4> is H, lower alkanoyl, (phenyl)-lower alkoxycarbonyl; R<3> and R<4> together may form formula II ((n) is 1 or 2) or formula III (R<6> is H or lower alkyl,), e.g. 3-amino-4-(4-fluorophenyl)-5-(2-pyridyl)-pyrazole. The compound expressed by formula I is e.g. obtained by reacting a nitrile derivative expressed by the formula R<1>-CH2CN with a carboxylic acid ester expressed by the formula R<3a>COOR<7> (R<3a> is pyridyl; R<7> is lower alkyl) in the presence of a base in an inert solvent to afford a compound expressed by formula IV and subjecting the compound expressed by formula IV to cyclic reaction with hydrazine. |
