| 摘要 |
<p>There are disclosed compounds of the formula <IMAGE> wherein R1 and R2 are each, independently, hydrogen, lower alkyl, aryl or halo, or R1 and R2 taken together represent -CH2-, -CH2CH2-, -O-, -NH-, <IMAGE> <IMAGE> <IMAGE> +TR <IMAGE> where the dotted lines represent optional double bonds; R3, R4, R5 and R6 are each, independently, hydrogen, lower alkyl, aryl or halo; R7 is 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl, 3-pyridazinyl or phenyl or any of the foregoing R7 moieties substituted by lower alkyl, trifluoromethyl, cyano, nitro or halo, with the proviso that when R1 and R2 taken together represent <IMAGE> then R7 is other than 2-pyridinyl, 2-pyrimidinyl or substituted pyrimidin-2-yl; Z is -(CH2)n-, vinylene, -O-, or <IMAGE> X is lower alkylene, vinylene, O or NH; m is 2-5; n is 0-4; o is 1-3; p is 1-4; and the pharmaceutically acceptable salts thereof, and their use as antipsychotic/anxiolytic agents having a low liability for extrapyramidal side effects.</p> |
