BEI SEHR NIEDRIGER TEMPERATUR ZERSTAEUBTE MIKROKUGELN MIT KONTROLLIERTER FREISETZUNG.
摘要
A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolved in the solvent or dispersed in the solvent in the form of microparticles. The polymer/active agent mixture is atomized into a vessel containing a liquid non-solvent, alone or frozen and overlayed with a liquified gas, at a temperature below the freezing point of the polymer/active agent solution. The cold liquified gas or liquid immediately freezes the polymer droplets. As the droplets and non-solvent for the polymer is warmed, the solvent in the droplets thaws and is extracted into the non-solvent, resulting in hardened microspheres.
申请公布号
DE69000573(D1)
申请公布日期
1993.01.21
申请号
DE1990600573
申请日期
1990.05.01
申请人
ENZYTECH, INC., CAMBRIDGE, MASS., US
发明人
GOMBOTZ, R., WAYNE, LEXINGTON, MA 02173, US;HEALY, S., MICHAEL, EAST BRIDGWATER, MA 02333, US;BROWN, R., LARRY, NEWTON, MA 02159-1753, US