AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY

摘要

Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents optionally substituted phenyl, naphthyl, indolyl, benzothiophenyl, benzofuranyl, benzyl or indazolyl; Z represents O, S or NR<8>; X and Y are H or are together =O; R<1> and R<2> are H; optionally substituted C1-6alkyl; optionally substituted phenyl(C1-4alkyl); COR; CO2R; CONRR; CONRCOOR; or SO2R; R<3> is H or C1-6alkyl, R<4> is H, C1-6alkyl or optionally substituted phenyl; and R<5> represents optionally substituted phenyl; are tachykinin antagonists. They and compositions thereof are useful in therapy.