| 摘要 |
<p>Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents optionally substituted phenyl, naphthyl, indolyl, benzothiophenyl, benzofuranyl, benzyl or indazolyl; Z represents O, S or NR8; X and Y are H or are together =O; R?1 and R2¿ are H; optionally substituted C¿1-6?alkyl; optionally substituted phenyl(C1-4alkyl); COR?c; CO¿2R?c; CONRcRd; CONRcCOORd¿; or SO¿2R?c; R3 is H or C¿1-6?alkyl, R?4¿ is H, C¿1-6?alkyl or optionally substituted phenyl; and R?5¿ represents optionally substituted phenyl; are tachykinin antagonists. They and compositions thereof are useful in therapy.</p> |
