DERIVATIVES OF ALPHA-HANP AND THEIR PRODUCTION

摘要

A peptide derivative of the formula wherein A is hydrogen or a hydrocarbon acyl having 2 to 18 carbon atoms which is substituted by an amino group at the alpha -position; B is F-Gly wherein F is a neutral alpha -amino acid residue, or NH-(CH2)nCO wherein n is an integer of 1 to 4; C is a neutral alpha -amino acid residue; and E is L-Arg or D-Arg; when A, B and C are hydrogen, Gly-Gly, and Met or Ile, respectively, E is D-Arg, or its pharmacologically acceptable salt has strong hypotensive and natriuretic activity; therefore it is useful as a therapeutic drug for hypertension, a diuretic, and a therapeutic drug for cardiac and cerebral circulatory diseases.