Piperidine derivative and pharmaceutical composition containing the same

摘要

A new piperidine compound is pharmacologically effective for treatment of the arrythmia and is defined by the formula: <IMAGE> in which R1 is a lower alkyl or a tolyl, R2 is hydrogen, hydroxyl, a lower alkoxy or a lower alkyl, R3 is hydrogen, a lower alkyl, a lower alkenyl, a cycloalkyl or a cycloalkylalkyl, X is -CO-, -CH2- or -CHOH-, g is an integer of 1 to 3, h is an integer of 1 to 3, Y is hydrogen, a lower alkyl, a lower alkenyl, cyano, CH2COOR, R being hydrogen or a lower alkyl, a cycloalkyl, a cycloalkylalkyl, <IMAGE> 1 being 1 or 2, -A-B, A being -(CH2)n-, n being an integer of 1 to 5, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkane having lower alkyl, phenyl or hydroxyl group(s) bonded directly to one or more carbon atoms constituting said alkane by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, a straight-chain alkylene group having 1 to 5 carbon atoms which is a divalent group derived from a straight-chain alkene having a double bond formed between carbon atoms adjacent to each other by removing a hydrogen atom bonded to each of the carbon atoms placed at both ends thereof, -(CH2)k-S-, k being an integer of 2 to 5, -(CH2)p-CO-, p being an integer of 1 to 4, B being cyano, -NR4R5, a heterocyclic ring or a condensed aromatic ring.