2-PHENYLBENZO(B)FURANS AND THIOPHENES, METHODS OF PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

摘要

Novel furans and thiophenes of the general formula I are described, in which R<1> and R<2> independently of one another denote a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a benzyl group, a group C(O)R<4>, where R<4> is an alkyl or alkoxy group having 1 to 10 carbon atoms or a phenyl radical, or a carbamoyl group -C(O)NR<5>R<6>, where R<5> and R<6> independently of one another are a hydrogen atom or an alkyl group having 1 to 10 carbon atoms, and n denotes an integer from 0 to 12 when R<3> is a hydrogen atom or n denotes an integer from 4 to 12 when R<3> is an amino group -NR<7>R<8>, where R<7> and R<8> independently of one another represent a hydrogen atom or an alkyl group having 1 to 10 carbon atoms or R<7>-R<8> together represent an alkylene group -(CH2)m- or the group -(CH2)2O(CH2)2- or R<3> denotes an amide group -C(O)NR<7>R<8>, where R<7> and R<8> have the abovementioned meanings, or R<3> denotes a sulphinyl group -S(O)R<9>, where R<9> is the radical -(CH2)m(CF2)oCF3 and m and o are 2, 3, 4, 5 or 6 and X is an oxygen or sulphur atom. The novel compounds have potent and selective antioestrogenic activity and are suitable for the treatment of oestrogen-dependent diseases.