MONOCLONAL ANTIBODY TO LYMPHOCYTE-ASSOCIATED CELL SURFACE PROTEIN

摘要

A hybridoma cell line produced by the fusion of NS-1 myeloma cells with sple en cells obtained from mice immunized with Leukocyte Adhesion Molecule-1 (LAM-1) cDNA transfected cells. The cell line produces a monoclonal antibody reactive wish human, monkey; cow, rabbit, sheep, dog, cat, pig and goat LAM-1. The monoclonal antibody produced by the cell line, anti- LAM1-3, may be clinically useful in blocking leukocyte entry into sites of inflammation or tissue injury.